Forest bathing-based Prophylatic/preventive therapy for SARS-COV-2/COVID-19: Forest bathing inhibits SARS-COV-2/1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  Foot and Mouth disease, ADV, Respiratory Syncytial,  Sindbis, and SFV viruses by increasing the Levels of the Interferon-alpha/beta/gamma/alpha2/lamda, Antiviral Proteins IFITM3, Interferon-stimulated gene 15, and others 27/June/2020, 11.14 pm

Ultraviolent-B (UVB)-based Prophylatic/preventive therapy for SARS-COV-2/COVID-19: UVB radiation inhibits SARS-COV-2/1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  Foot and Mouth disease, ADV, Respiratory Syncytial,  Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, Interferon-stimulated gene 15, and others 13/May/2020, 10.48 pm
May 13, 2020
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Introduction: What they say:

A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA shows that “The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.” This study was published, in the 24 December 2009 issue of the journal “Cell” (the number 1 research journal in General Biology with an impact factor of 33),  by the 2015 Laskar award winner Prof. Stephen Elledge, Brass and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports that: Ultraviolent-B (UVB)-based Prophylatic/preventive therapy for SARS-COV-2/COVID-19: UVB radiation inhibits SARS-COV-2/1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  Foot and Mouth disease, ADV, Respiratory Syncytial,  Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, Interferon-stimulated gene 15, and others 13/May/2020, 10.48 pm


What is known?

Prof. Stephen Elledge research team has showed that interferon-inducible transmembrane proteins IFITM1, 2, and 3 inhibit  influenza A H1N1 virus, West Nile virus, and dengue virus replication, suggesting that increasing the expression of IFITM3 may confer resistance against these viruses. Other studies suggest that IFITM3 may also protect against Ebola virus, hepatitis C virus, yellow fever virus and SARS coronavirus etc.


From research findings to therapeutic opportunity: 

This study suggests, for the first time, that forest bathing, with detailed mechanistic insights, can reduce the chances of getting COVID-19 and other infectious diseases. Forest bathing, by increasing the expression of its target genes, it could activate NK cells, increase the expression of antiviral Proteins, such as Interferon-alpha/beta/gama/alpha2/lamda, Antimicrobial peptides (AMPs), IFITM3, Interferon-stimulated gene 15, Mx2 and others. Thereby, it could: (1) inhibit the replication of  SARS-COV-2, SARS-COV-1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  Foot and Mouth disease, ADV, respiratory syncytial,  Sindbis, and SFV viruses; (2) confer resistance against  infection caused by SARS-COV-2, SARS-COV-1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Foot and Mouth disease, ADV, Influenza H1NI1,  respiratory syncytical,  Sindbis, and SFV viruses; and (3) promote innate immunity (Figures 1-5)

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Figure 1. Mechanistic insight into how Forest bathing (breathing) could prevent/protect against SARS-COV-2. Forest bathing inhibits SARS-COV-2 &  SARS-COV-1 production, activates NK cells, induces antiviral Proteins Interferon-alpha/beta/gama/alpha2/lamda, Antimicrobial peptides (AMPs), IFITM3, Interferon-stimulated gene 15, Mx2 and others.

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Figure 2 Mechanistic insight into how forest bathing functions as a broad spectrum anti-infective agent. Forest bathing inhibits SARS-COV-2, SARS-COV-1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial , Sindbis, Foot and Mouth disease virus, ADV, and SFV viruses production through activation of NK cells, induction of its target genes, such as antiviral Proteins Interferon-alpha/beta/gama/alpha2/lamda, Antimicrobial peptides (AMPs), IFITM3, Interferon-stimulated gene 15, Mx2 and others.

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Figure 3. Forest bathing can function as a broad-spectrum anti-infective agent through induction of its target genes.

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Figure 4.  Forest bathing can attenuate the production of SARS-COV-2 and protect against SARS-COV-2.

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Thus, forest bathing/breathing can be used to prevent/treat/protect against infections caused by SARS-COV-2, SARS-COV-1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Foot and Mouth disease, ADV (Adenovirus), Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses.


Details of the research findings: 

Idea formulated by Dr L Boominathan PhD

Undisclosed information: How forest bathing/breathing  increases the expression of antiviral Protein, such as IFITM3, Interferon-stimulated gene 15, Mx2, and others

Type: Research cooperation

For more details on research cooperation, you may reach us at drboomi@genomediscovery.org or admin@genomediscovery.org


References: 

CitationBoominathan L, Forest bathing-based Prophylatic/preventive therapy for SARS-COV-2/COVID-19: Forest bathing inhibits SARS-COV-2/1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  Foot and Mouth disease, ADV, Respiratory Syncytial,  Sindbis, and SFV viruses by increasing the Levels of the Interferon-alpha/beta/gamma/alpha2/lamda, Antiviral Proteins IFITM3, Interferon-stimulated gene 15, and others 27/June/2020, 11.14 pm

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