A possible vaccine against SARS-COV-2: Repurposing the MMR vaccine (Measles, Mumps, and Rubella) into a Prophylactic MMR-COVID-19 vaccine: MMR vaccine inhibits SARS-COV-2, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  Foot and Mouth disease, ADV, respiratory syncytial, Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, Interferon-stimulated gene 15, and others 26/July/2020, 6.13 am

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Introduction: What they say:

A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA shows that “The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.” This study was published, in the 24 December 2009 issue of the journal “Cell” (the number 1 research journal in General Biology with an impact factor of 33),  by the 2015 Laskar award winner Prof. Stephen Elledge, Brass and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: A vaccine against SARS-COV-2: Repurposing the MMR vaccine (Measles, Mumps, and Rubella) into a Prophylactic MMR-COVID-19 vaccine: MMR vaccine inhibits SARS-COV-2, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  Foot and Mouth disease, ADV, respiratory syncytial, Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, Interferon-stimulated gene 15, and others


What is known?

Prof. Stephen Elledge research team has showed that interferon-inducible transmembrane proteins IFITM1, 2, and 3 inhibit  influenza A H1N1 virus, West Nile virus, and dengue virus replication, suggesting that increasing the expression of IFITM3 may confer resistance against these viruses. Other studies suggest that IFITM3 may also protect against Ebola virus, hepatitis C virus, yellow fever virus and SARS coronavirus etc.


From research findings to therapeutic opportunity: 

This study suggests, for the first time, that MMR (Measles, Mumps, and Rubella) vaccine-based therapy, with detailed mechanistic insights, for COVID-19 and other infectious diseases. MMR vaccine, by increasing the expression of its target genes, it may increase the expression of interferon-inducible transmembrane protein IFITM3, Interferon-stimulated gene-15, Mx2 and antimicrobial peptides. Thereby, it could: (1) inhibit the replication of  SARS-COV-2, SARS-COV-1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  Foot and Mouth disease, ADV, respiratory syncytial,  Sindbis, and SFV viruses; (2) confer resistance against  infection caused by SARS-COV-2, SARS-COV-1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Foot and Mouth disease, ADV, Influenza H1NI1,  respiratory syncytical,  Sindbis, and SFV viruses; and (3) promote innate immunity (Figs. 1-3) Thus, pharmacological formulations encompassing “MMR vaccine, either alone or in combination with other drugs/compounds, can be used to prevent/treat/protect against infections caused by SARS-COV-2, SARS-COV-1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Foot and Mouth disease, ADV (Adenovirus), Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses (Figs. 1-3).

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Figure 1. Mechanistic insight into how MMR vaccine prevents/protects against SARS-COV-2. MMR vaccine inhibits SARS-COV-2 &  SARS-COV-1 through induction of its target genes, such as IFN (Interferon)-alpah/alpha-2/beta/gamma/lamda, antiviral Proteins IFITM3, Interferon-stimulated gene 15, Mx2, and others.

This image has an empty alt attribute; its file name is MMR-vaccine-aids-in-attenuation-of-a-number-of-infectious-diseases-including-COVID-19.jpg2_-770x433.jpg

Figure 2 Mechanistic insight into how MMR vaccine functions as a broad spectrum anti-infective agent. MMR vaccine inhibits SARS-COV-2, SARS-COV-1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial , Sindbis, Foot and Mouth disease virus, ADV, and SFV viruses production through induction of its target genes, such as IFN (Interferon)-alpah/alpha-2/beta/gamma/lamda, antiviral Proteins IFITM3, Interferon-stimulated gene 15, Mx2, antiviral Proteins IFITM3, Interferon-stimulated gene 15, Mx2 and others.

This image has an empty alt attribute; its file name is MMR-vaccine-aids-in-attenuation-of-a-number-of-infectious-diseases-including-COVID-19.jpg3_-770x433.jpg

Figure 3.  MMR vaccine can function as a broad-spectrum anti-infective agent.

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Figure 4.  Repurposing the MMR vaccine into a SARS-COV-2 (MMR-SARS-COV vaccine) vaccine. GBMD (genomediscovery.org) is looking for Scientists/Professor/Medical faculties who would be interested in collaborating with us in exploring the bio-medical mechanisms and in carrying out clinical trial.


Details of the research findings: 

Idea formulated by Dr L Boominathan PhD

Undisclosed information: How MMR vaccine increases the expression of antiviral Protein IFITM3, Interferon-stimulated gene 15, & Mx2

Type: Research cooperation

For more details on research cooperation, you may reach us at drboomi@genomediscovery.org or admin@genomediscovery.org


References: 

CitationBoominathan L, A possible vaccine against SARS-COV-2: Repurposing the MMR vaccine (Measles, Mumps, and Rubella) into a Prophylactic MMR-COVID-19 vaccine: MMR vaccine inhibits SARS-COV-2, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  Foot and Mouth disease, ADV, respiratory syncytial, Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, Interferon-stimulated gene 15, and others 26/July/2020, 6.13 am

Courtesy: When you cite drop us a line at info@genomediscovery.org,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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