Natural product-based therapy for COVID-19 and other infectious diseases: Fucoidan-based therapy for SARS-COV-2: Fucoidan, a fucose-enriched and sulfated polysaccharide, inhibits SARS-COV-2/1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  Foot and Mouth disease, ADV, respiratory syncytial, Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, Interferon-stimulated gene 15, and others 1/August/2020, 9.08 am

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August 1, 2020
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Introduction: What they say:

A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA shows that “The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.” This study was published, in the 24 December 2009 issue of the journal “Cell” (the number 1 research journal in General Biology with an impact factor of 33),  by the 2015 Laskar award winner Prof. Stephen Elledge, Brass and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for COVID-19 and other infectious diseases: Fucoidan-based therapy for SARS-COV-2: Fucoidan, a fucose-enriched and sulfated polysaccharide, inhibits SARS-COV-2/1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  Foot and Mouth disease, ADV, respiratory syncytial, Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, Interferon-stimulated gene 15, and others 1/August/2020, 9.08 am


What is known?

Prof. Stephen Elledge research team has showed that interferon-inducible transmembrane proteins IFITM1, 2, and 3 inhibit  influenza A H1N1 virus, West Nile virus, and dengue virus replication, suggesting that increasing the expression of IFITM3 may confer resistance against these viruses. Other studies suggest that IFITM3 may also protect against Ebola virus, hepatitis C virus, yellow fever virus and SARS coronavirus etc.


From research findings to therapeutic opportunity: 

Fucoidan, a fucose-enriched and sulfated polysaccharide, found in extracellular matrix of various species of brown algae and brown seaweed, including wakame, kombu, fucus vesiculosus (bladder wrack) and others.

It has been found to be effective against a number of infectious diseases. However, it mechanism of action remains largely unknown. 

This study suggests, for the first time, that Oligo-fucoidanbased therapy, with detailed mechanistic insights, for COVID-19 and other infectious diseases(Fig.1). Oligo-fucoidan, by increasing the expression of its target genes, it may increase the expression of IFN (Interferon)-alpah/alpha-2/beta/gamma/lamda, interferon-inducible transmembrane protein IFITM3, Interferon-stimulated gene-15, Mx2 and antimicrobial peptides (Fig.1-3). Thereby, it could: (1) inhibit/prevent the entry/fusion/replication/production of  SARS-COV-2, SARS-COV-1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  Foot and Mouth disease, ADV, respiratory syncytial,  Sindbis, and SFV viruses; (2) confer resistance against  infection caused by SARS-COV-2, SARS-COV-1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Foot and Mouth disease, ADV, Influenza H1NI1,  respiratory syncytical,  Sindbis, and SFV viruses; and (3) promote innate immunity (Figs. 1-4) Thus, pharmacological formulations encompassing ” Oligo-fucoidan or its derivatives or its mechanistic equivalents, either alone or in combination with other drugs/compounds, can be used to prevent/treat/protect against infections caused by SARS-COV-2, SARS-COV-1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Foot and Mouth disease, ADV (Adenovirus), Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses (Figs. 1-5).

Figure 1. Mechanistic insight into how Fucoidan prevents/protects against SARS-COV-2. MMR vaccine inhibits SARS-COV-2 &  SARS-COV-1 through induction of its target genes, such as IFN (Interferon)-alpah/alpha-2/beta/gamma/lamda, antiviral Proteins IFITM3, Interferon-stimulated gene 15, Mx2, and others.

Figure 2 Mechanistic insight into how Oligo-fucoidan functions as a broad spectrum anti-infective agent. MMR vaccine inhibits SARS-COV-2, SARS-COV-1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial , Sindbis, Foot and Mouth disease virus, ADV, and SFV viruses production through induction of its target genes, such as IFN (Interferon)-alpah/alpha-2/beta/gamma/lamda, antiviral Proteins IFITM3, Interferon-stimulated gene 15, Mx2, antiviral Proteins IFITM3, Interferon-stimulated gene 15, Mx2 and others.

Figure 3.  Oligo-fucoidan can be used to treat/prevent/boost one’s immunity against SARS-COV-2 and COVID-19.

Figure 4.  Oligo-fucoidan, derived from extracellular matrix of wakame, kombu, fucus vesiculosus(bladder wrack) and others, can function as a immune booster against SARS-COV-2 and other infectious diseases and thereby serve as a broad-spectrum anti-infective agent.

Figure 5.  Natural product-based (Fucoidan) therapy for COVID-19 and other infectious diseases. GBMD (genomediscovery.org) is looking for Bio-Medical Scientists/Professor/Medical faculties/Clinicians who would be interested in collaborating with us in exploring the bio-medical mechanisms and in carrying out clinical trial.


Details of the research findings: 

Idea formulated by Dr L Boominathan PhD

Undisclosed information: How Fucoidan increases the expression of antiviral Protein IFITM3, Interferon-stimulated gene 15, & Mx2

Type: Research cooperation

For more details on research cooperation, you may reach us at drboomi@genomediscovery.org or admin@genomediscovery.org


References: 

CitationBoominathan L, Natural product-based therapy for COVID-19 and other infectious diseases: Fucoidan-based therapy for SARS-COV-2: Fucoidan, a fucose-enriched and sulfated polysaccharide, inhibits SARS-COV-2/1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  Foot and Mouth disease, ADV, respiratory syncytial, Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, Interferon-stimulated gene 15, and others 1/August/2020, 9.08 am

Courtesy: When you cite drop us a line at info@genomediscovery.org,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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