Honey-based therapy for COVID-19 and other infectious diseases: Manuka honey-based therapy for SARS-COV-2: Manuka honey, can be obtained from the nectar of Manuka tree (Leptospermum scoparium), inhibits SARS-COV-2, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  Foot and Mouth disease, ADV, respiratory syncytial, Sindbis, and SFV viruses and others by increasing the levels of IFN (Interferon)-alpah/alpha-2/beta/gamma/lamda, interferon-inducible transmembrane protein IFITM3, Interferon-stimulated gene-15, Mx2 and antimicrobial peptides 24/August/2020, 12.07 am

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Introduction: What they say:

A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA shows that “The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.” This study was published, in the 24 December 2009 issue of the journal “Cell” (the number 1 research journal in General Biology with an impact factor of 33),  by the 2015 Laskar award winner Prof. Stephen Elledge, Brass and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Honey-based therapy for COVID-19 and other infectious diseases: Manuka honey-based therapy for SARS-COV-2: Manuka honey, can be obtained from the nectar of Manuka tree (Leptospermum scoparium), inhibits SARS-COV-2, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  Foot and Mouth disease, ADV, respiratory syncytial, Sindbis, and SFV viruses and others by increasing the levels of IFN (Interferon)-alpah/alpha-2/beta/gamma/lamda, interferon-inducible transmembrane protein IFITM3, Interferon-stimulated gene-15, Mx2 and antimicrobial peptides 24/August/2020, 12.07 am


What is known?

Prof. Stephen Elledge research team has showed that interferon-inducible transmembrane proteins IFITM1, 2, and 3 inhibit  influenza A H1N1 virus, West Nile virus, and dengue virus replication, suggesting that increasing the expression of IFITM3 may confer resistance against these viruses. Other studies suggest that IFITM3 may also protect against Ebola virus, hepatitis C virus, yellow fever virus and SARS coronavirus etc.


From research findings to therapeutic opportunity: 

Manuka honey can be obtained from the nectar of Manuka tree (Leptospermum scoparium). It has been shown to  protect against infections caused by E.Coli,  S.aureus, and others. However, its mechanism of action remains largely elusive. 

I have published earlier that honey could play a role in protecting against  myocardial dysfunction and in extending lifespan (https://genomediscovery.org/2020/02/mechanistic-insights-into-how-blue-zone-longevity-diet-protects-against-cardiac-dysfunction-having-honey-on-a-daily-basis-will-protect-you-against-cardiac-dysfunction-and-extend-lifespanchrysin-fou/https://genomediscovery.org/2020/02/mechanistic-insights-into-how-blue-zone-longevity-diet-protects-against-cardiac-dysfunction-having-honey-on-a-daily-basis-will-protect-you-against-cardiac-dysfunction-and-extend-lifespanchrysin-fou/)

This study suggests, for the first time, that Manuka honey-derived compounds, such as Methyl Glyoxal (MGO), Gallic acid, Quercetin and other flavonoids, could protect against infections caused by a number of viruses, including SARS-COV-2, and thereby protect against COVID-19 (Fig.1).

Manuka honey, by increasing the expression of its target genes, it could increase the expression of IFN (Interferon)-alpah/alpha-2/beta/gamma/lamda, interferon-inducible transmembrane protein IFITM3, Interferon-stimulated gene-15, Mx2 and antimicrobial peptides (Figs.1-4). Thereby, it could: (1) inhibit/prevent the entry/fusion/replication/production of  SARS-COV-2, SARS-COV-1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  Foot and Mouth disease, ADV, respiratory syncytial,  Sindbis, and SFV viruses; (2) confer resistance against  infection caused by SARS-COV-2, SARS-COV-1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Foot and Mouth disease, ADV, Influenza H1NI1,  respiratory syncytical,  Sindbis, and SFV viruses; and (3) promote innate immunity (Figs. 1-6)

Furthermore, Manuka honey could protect against clinical complications associated with severe COVID-19 patients, such as acute respiratory distress syndrome, cytokine storm, leukopenia and others.

Figure 1. Mechanistic insight into how Manuka honey prevents/protects against SARS-COV-2. Manuka honey inhibits SARS-COV-2 &  SARS-COV-1 production through induction of its target genes, such as IFN (Interferon)-alpah/alpha-2/beta/gamma/lamda, antiviral Proteins IFITM3, Interferon-stimulated gene 15, Mx2, and others.

Figure 2.  Manuka honey, derived from the nectar of manuka tree, can function as an immune booster against SARS-COV-2 and other infectious diseases, and thereby serves as a broad-spectrum anti-infective agent.

Figure 3 Mechanistic insight into how Manuka honey functions as a broad spectrum anti-infective agent. Methyl Glyoxal (MGO), Gallic acid, and Quercetin, found in Manuka honey, inhibit fusion/entry/replicaition/production of SARS-COV-2, and SARS-COV-1,  viruses through induction of their target genes, such as IFN (Interferon)-alpah/alpha-2/beta/gamma/lamda, antiviral Proteins IFITM3, Interferon-stimulated gene 15, Mx2, antiviral Proteins IFITM3, Interferon-stimulated gene 15, Mx2 and others.

Figure 4.  Manuka honey functions as a broad-spectrum anti-infective agent. Manuka honey, derived from the nectar of Manuka flowers, can be used to treat/prevent/boost one’s immunity against COVID-19, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial , Sindbis, Foot and Mouth disease virus, ADV, SFV viruses production and others.

Figure 5 Mechanistic insight into how Manuka honey functions as a broad spectrum anti-infective agent. Methyl Glyoxal, Gallic acid, and Quercetin, found in Manuka honey, inhibit SARS-COV-2, SARS-COV-1, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial , Sindbis, Foot and Mouth disease virus, ADV, and SFV viruses production through induction of their target genes, such as IFN (Interferon)-alpah/alpha-2/beta/gamma/lamda, antiviral Proteins IFITM3, Interferon-stimulated gene 15, Mx2, antiviral Proteins IFITM3, Interferon-stimulated gene 15, Mx2 and others.

Figure 6.  Manuka honey-based therapy for COVID-19 and other infectious diseases. GBMD (genomediscovery.org) is looking for Bio-Medical Scientists/Professor/Medical faculties/Clinicians who would be interested in collaborating with us in exploring the bio-medical mechanisms and in carrying out clinical trial.

Thus, pharmacological formulations encompassing “Manuka honey or its components, such as Methyl Glyoxal, Gallic acid, and Quercetin, or its mechanistic equivalents, either alone or in combination with other drugs/compounds, can be used to prevent/treat/protect against infections caused by SARS-COV-2 (COVID-19), SARS-COV-1 (SARS), Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Foot and Mouth disease, ADV (Adenovirus), Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses (Figs. 1-5).


Details of the research findings: 

Idea formulated by Dr L Boominathan PhD

Undisclosed information: How manuka honey increases the expression of IFN (Interferon)-alpah/alpha-2/beta/gamma/lamda, antiviral Proteins IFITM3, Interferon-stimulated gene 15, Mx2, antiviral Proteins IFITM3, Interferon-stimulated gene 15, and Mx2

Type: Research cooperation

For more details on research cooperation, you may reach us at drboomi@genomediscovery.org 


References: 

CitationBoominathan L, Honey-based therapy for COVID-19 and other infectious diseases: Manuka honey-based therapy for SARS-COV-2: Manuka honey, can be obtained from the nectar of Manuka tree (Leptospermum scoparium), inhibits SARS-COV-2, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  Foot and Mouth disease, ADV, respiratory syncytial, Sindbis, and SFV viruses and others by increasing the levels of IFN (Interferon)-alpah/alpha-2/beta/gamma/lamda, interferon-inducible transmembrane protein IFITM3, Interferon-stimulated gene-15, Mx2 and antimicrobial peptides 24/August/2020, 12.09 am

Courtesy: When you cite drop us a line at drboomi@genomediscovery.org,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org

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