Sleeve gastrectomy as a regenerative cardiovascular therapy: Sleeve gastrectomy inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte proliferation, regeneration, and survival after myocardial infarction, via up-regulation of its target gene, 6/January/2021, 11.33 pm

Regenerative cardiovascular therapy: ELK1 inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte proliferation, regeneration, and survival after myocardial infarction, via up-regulation of its target gene, 1/January/2021, 11.49 pm
January 1, 2021
Regenerative cardiovascular therapy: TRIM29 (Tripartite Motif Containing 29) inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte proliferation, regeneration, and survival after myocardial infarction, via up-regulation of its target gene, 20/January/2021, 8.37 pm
January 20, 2021
Show all

What they say

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of the journal Nature,  by Profs. Stefanie Dimmeler (Director, Center for Molecular Medicine), Reinier A Boon and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Sleeve gastrectomy as regenerative cardiovascular therapy:  Sleeve gastrectomy inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte proliferation, regeneration, and survival after myocardial infarction, via up-regulation of its target gene, 6/January/2021, 11.33 pm


From Significance of the study to Public Health relevance:

Given that: (1)  cardiovascular disease is the leading cause of death worldwide; (2) the raise of death rate, due to cardiovascular disease, has increased from  123 lakhs in 1990 to 173 lakhs in 2013; (3) 85% of people over 80 years are susceptible to cardiovascular diseases;(4) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; (3) the death due to cardiovascular disease is higher in low-to-middle income countries compared to developed countries; (4) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars; (5) an alarming number of people, such as 230 lakhs people, will die from cardiovascular diseases each year by 2030, there is an urgent need to find: (i) a way to induce regeneration of cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iv) a side-effect-free Natural product-based drug.


From Research Findings to Therapeutic Opportunity

This study suggests, for the first time, that Sleeve gastrectomy could protect against myocardial dysfunction. 

Sleeve gastrectomy, by decreasing the expression of its target genes, it could increase the expression of PNUTS (fig.1)Thereby, it may: (1) inhibit DNA damage responses, (2) increase telomerase expression, (3) inhibit telomere shortening; (4) promote cardiomyocyte survival/regeneration/proliferation; (5) decelerate aging; and (6) extend lifespan (fig 1).  

Figure 1. Sleeve gastrectomy functions as a Cardioprotective agent. Sleeve gastrectomy prevents myocardial dysfunction and promotes cardiac regeneration/survival through induction of PNUTS, Telomerase and stem cell factors. 
Figure 2.  Sleeve Gastrectomy functions as a cardioprotective agent through induction of PNUTS.
Figure 3. While it had been shown earlier that increased expression of PNUTS protects against myocardial dysfunction, this study suggests that Sleeve gastrectomy may promote cardiac repair and protect against cardiac ageing and myocardial infarction through induction of PNUTS, telomerase and other genes.

Thus, by making aged cardiac patients undergo Sleeve gastrectomy, one may prevent ageing-associated (or, stress-associated) decline in cardiac function. Together, this study suggests, for the first time, that Sleeve gastrectomy, either alone or in combination with other cardio protective drugs, may be used to protect against myocardial infarction or improve cardiac function after myocardial infarction (figs. 1-3). 


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Sleeve gastrectomy increase the expression of PNUTS/Telomerase?

Amount: $ 1, 500 #

# Research cooperation

For purchase and payment details, you may reach us at admin@genomediscovery.org


References:

Web: http://genomediscovery.org or http://newbioideas.com/

CitationBoominathan, L., Sleeve gastrectomy as regenerative cardiovascular therapy:  Sleeve gastrectomy inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte proliferation, regeneration, and survival after myocardial infarction, via up-regulation of its target gene, 6/January/2021, 11.33 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at admin@genomediscovery.org

Comments are closed.