Regenerative therapy for curing Glaucoma: Sildenafil increases the expression of genes that promote regeneration,  promotes reprogramming of aged eye cells, increases telomerase expression, increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against and reverses glaucoma,  via up-regulation of its target gene, 20/January/2021, 9.29 pm

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Introduction: What they say

A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, USA; The Howard Hughes Medical Institute, Bar Harbor, ME 04609, USA shows that Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice.” This research paper was published, in the 9 February 2017 issue of the journal “Science” [One of the best research journals in “General Science” with an I.F of 41.063], by     Prof. Simon W. M. John and Pete A. Williams and others.


What we say: From research findings to Therapeutic opportunity:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Regenerative therapy for curing Glaucoma: Sildenafil increases the expression of genes that promote regeneration,  promotes reprogramming of aged eye cells, increases telomerase expression, increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against and reverses glaucoma,  via up-regulation of its target gene


From the significance of the study to public health relevance:

Given that: (1) Glaucoma is a neurodegenerative disease; (2) more than 80 million people worldwide are affected by Glaucoma; (2) Glaucoma is the second leading cause of blindness; (3) Glucosma has no cure; (4) vision lost due to glaucoma is irreversible; (5) the global economic cost spent for Glaucoma treatment is enormous, there is an urgent need to find: (i) a way to induce regeneration of ganglion cells that were lost in Glaucoma; (ii) a cheaper alternative to the existing expensive anti-glaucoma drugs; (iii) a side-effect-free natural product-based drug; and (v) a way to cure, not just treat, Glaucoma permanently.


What is known?

Prof.Simon’s research team has recently shown that:(1) glaucoma-prone mice suffer from mitochondrial abnormalities, resulting in neuronal dysfunction; (2) NAD+ levels decrease with age; (3) administration of Niacin/Vitamin-B3 protects against glaucoma; (4) expression of Nmnat1, a key NAD+-producing enzyme, protects against glaucoma, suggesting that increasing the expression of Nmnat1 in glaucoma patients may alleviate glaucoma.


From research findings to Therapeutic opportunity:

This study suggests, for the first time, that Sildenafil, by increasing the expression of its target genes, it could increase the expression of Nmnat1. Thereby, it could: (1) increase NAD+ levels; (2) increase telomerase expression; (3) increase the expression of genes that promote regeneration; (4) promote reprogramming of aged eye cells; (5) decrease Intraocular pressure; (6) improve pressure-induced damage; (7) increase insulin sensitivity; and (8) alleviate/reverse/cure glaucoma (Fig.1).

Figure 1. Mechanistic insights into how Sildenafil attenuates or cures glaucoma. Sildenafil, by increasing the expression of its target genes,  increases the expression of genes that promote regeneration and telomerase, enhances NAD+ levels, and attenuates/reverses/cures glaucoma.

This image has an empty alt attribute; its file name is Sildenafil-Increases-NMN.NAD-levels-inhibits-Intraocular-pressure-induced-damage-and-attenuates-glaucoma-2-770x578.jpg

Figure 5. Sildenafil functions as an anti-glaucoma agent by increasing NAD+ levels , and by promoting regeneration of aged eye cells

This image has an empty alt attribute; its file name is Sildenafil-Increases-NMN.NAD-levels-inhibits-Intraocular-pressure-induced-damage-and-attenuates-glaucoma-3-770x578.jpg

Figure 6. While it had been shown earlier that Vitamin-B3 prevents glaucoma in aged mice, its mechanism of action remains unclear. This study suggests that Sildenafil  could promote reprogramming of aged eye cells and reverse glaucoma by upregulating the expression of NMNAT1, and telomerase,  increase the levels of NAD+, and genes that promote regeneration.

Thus, Sildenafil,  either alone or in combination with other drugs or compounds, can be used to cure or reverse or treat Glaucoma.


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Sildenafil increase the levels of NMNAT1, telomerase, and NAD+?

Amount: $1, 500#

# Research cooperation

For purchase and payment details, you may reach us at info@genomediscovery.org


References:

Web: http://genomediscovery.org or http://newbioideas.com

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Citation: Boominathan, L.,   Regenerative therapy for curing Glaucoma: Sildenafil increases the expression of genes that promote regeneration,  promotes reprogramming of aged eye cells, increases telomerase expression, increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against and reverses glaucoma,  via up-regulation of its target gene, 20/January/2021, 9.29 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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