- A study from the Department of Clinical and Molecular Cardiovascular Research, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan; Department of Cardiology, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan; and JST CREST, Shinjuku-ku Tokyo, Japan has reported that “MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing …”
- This study was published in the 11 June 2014 EMBO Journal by Prof. Ieda M, Muraoka N and others from the Department of Clinical and Molecular Cardiovascular Research, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan Department of Cardiology, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan.
- On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that:Therapeutic insights into making the highly efficient cardiomyocyte-like cells from differentiated cells: Tanshinone IIA, a well-known chinese medicine, promotes cardiac reprogramming by suppressing Snai expression. This study suggests that Tanshinone IIA, by suppressing the expression of its target gene, it could increase the number of beating cardiomyocyte-like cells (iCMs). Taken together, this study suggests that (1) pharmacological formulations containing “Tanshinone IIA” can be used to increase the number of beating cardiomyocyte-like cells (iCMs); and (2) Tanshinone IIA can be used to promote cardiac repair.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Therapeutic insights into making the highly efficient cardiomyocyte-like cells: Tanshinone IIA, a well-known chinese medicine, promotes cardiac reprogramming by suppressing Snai expression, 14/June/2014, 5.49 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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