A study from Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Netherland has reported that “Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease.” Another related study from National Heart, Lung, and Blood Institute, Netherland has reported that “Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease.” The data presented in these research papers suggest that mutation or reduction in APOC3 may prevent tiglycerides accumulation and coronary disease.
Both studies were published in the 18 Jun 2014 N Engl J Med. (IF:51.66) by Prof. Hansen A, Jørgensen AB and others from Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Netherland; and Scientists from National Heart, Lung, and Blood Institute, Netherland.
On the foundation of these interesting findings, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Insights into the treatment of hypertriglyceridemia and coronary disease: Fisetin, a natural compound isolated from strawberries, suppresses the expression of apolipoprotein C3 (APOC3) via down regulation of its target gene. Given that muations that disrupt the function of APOC3 are associated with lower levels of Triglycerides, small molecule compound, such as Fisetin, which lowers the levels of APOC3, may have similar pharmacological effect. Together, this study suggests that pharmacological formulations containing “Fisetin or its analogues” can be used in the treatment of coronary and ischemic vascular disease.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Insights into the treatment of hypertriglyceridemia and coronary disease: Fisetin, a natural compound isolated from strawberries, suppresses the expression of apolipoprotein C3 (APOC3) via down regulation of its target gene, 21/June/2014, 6.39 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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