Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Natural product-based therapy for Cancer: Salvianolic acid B, an antioxidant, inhibits the progression of p53 mutant tumors via induction of tumor suppressor p53 homologs TAp73 and TAp63, 8/August/2014, 5.58 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: Tumor suppressor p53 is mutated in most of the human tumors. However, its structural and functional homologues p73 and p63 are rarely mutated. Based on this, this study suggests a therapeutic strategy as to how mutant p53 expressing human cancers can be cured. Salvianolic acid B, by inducing the expression of its target gene, it may induce the expression of p73 and p63. Together, this study suggests that pharmacological formulations encompassing “Salvianolic acid B or its analogues” can be used to treat mutant p53-expressing tumors.
