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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Molecular therapy for Metastatic tumors: Deubiquitylating enzyme DUBA decreases the levels of PD-1, a suppressor of activation of T-cells, via down regulation of its target gene, 20/February/2015, 13.16, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: This study suggests that DUBA, by decreasing the levels of its target gene, it may suppress the expression of PD-1.  Thereby, it may activate the immune system and inhibit metastasis. Thus, pharmacological formulations encompassing “DUBA activators  may be used to inhibit tumorigenesis.

Amount: $ 300*

Undisclosed information: How DUBA suppresses the expression of PD-1

Web: http://genomediscovery.org

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