A recent study from the Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA shows that Stress Induces p38-Mediated Phosphorylation and Inhibition of Drosha-Dependent Cell Survival. This study was published in the 19 February 2015 issue of the Journal Molecular Cell [I.F:>14.4] by Drs. Zixu Mao, Qian Yang and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Therapeutic insights into the treatment of Oligoteratozoospermia and Azoospermia: Stem cell protein Oct-4 promotes Drosha-dependent cell survival and normal spermatogenesis and male fertility via up regulation of its target gene. This study suggests, for the first time, Oct-4, by increasing the expression of its target gene, it may increase: (1) the expression of Drosha, and (2) normal spermatogenesis and male fertility. Further, this study suggests that stress-induced p38, by suppressing the expression of Drosha, may inhibit spermatogenesis. Together, pharmacological formulations encompassing “Oct-4 activators” may be used to (1) treat patients suffering from Oligoteratozoospermia and Azoospermia; and (2) boost male fertility.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Therapeutic insights into the treatment of Oligoteratozoospermia and Azoospermia: Stem cell protein Oct-4 promotes Drosha-dependent cell survival and normal spermatogenesis and male fertility via down regulation of its target gene, 2/March/2015, 15.18, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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* Research cooperation
Undisclosed information: How Oct-4 promotes Drosha-dependent cell survival and spermatogenesis and fertility
Amount: $500*
