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A recent study from the Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA shows that Stress Induces p38-Mediated Phosphorylation and Inhibition of Drosha-Dependent Cell Survival. This study was published in the 19 February 2015 issue of the Journal Molecular Cell [I.F:>14.4] by Drs. Zixu Mao, Qian Yang and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for Oligoteratozoospermia and Azoospermia: Garlic promotes Drosha-dependent cell survival and normal spermatogenesis and male fertility via up regulation of its target gene. This study suggests, for the first time, Garlic, by increasing the expression of its target gene, it may increase: (1) the expression of Drosha; (2) normal spermatogenesis; and (3) male fertility. Further, this study suggests that stress-induced p38, by suppressing the expression of Drosha, may inhibit spermatogenesis. Together, pharmacological formulations encompassing Garlic  or small molecule compounds isolated from garlic extract” may be used to (1) treat patients suffering from Oligoteratozoospermia and Azoospermia; and (2) boost male fertility. 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan,  Natural product-based therapy for Oligoteratozoospermia and Azoospermia: Garlic promotes Drosha-dependent cell survival and normal spermatogenesis and male fertility via up regulation of its target gene, 4/March/2015,  8.43 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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* Research cooperation

Undisclosed information: How Garlic promotes Drosha-dependent cell survival and spermatogenesis and fertility

Amount: $500*


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