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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, L., Small molecule-based Life-span extension therapy: 5-aminoimidazole-4-carboxamide riboside (AICAR), an analog of AMP, inhibits senescence and  extends lifespan by up regulating the expression of  longevity gene Sirtuin-1, 8/April/2015, 23.51, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Significance: This study suggests, for the first time, that AICAR, by decreasing the expression of its target gene,  it may increase the expression of Sirtuin-1. Thereby, it may extend the lifespan of an individual. Thus, pharmacological formulations encompassing AICAR or its analogues may be used to extend the life-span of an an individual.

Undisclosed information: How AICAR increases the expression of Sirtuin-1

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