A recent study from the Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland shows that “HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase.” This study was published in the 3 June 2010 issue of the Journal “Nature” (I.F: 42 ) by Prof Hengartner MO, Sendoel A and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Targeted molecular therapy for HIF-overexpressing tumors: Deltex1 promotes p53-mediated apoptosis via down regulation of TYR-2/TRP2/DCT
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Significance: This study suggests that Deltex1, by decreasing the expression of its target gene, it may increase the expression of tumor suppressor p53. Thereby, it may promote tumor suppression. Thus, pharmacological formulations encompassing “Deltex1 activators“ may be used to treat human tumors that over express HIF protein.
Citation: Boominathan, Targeted molecular therapy for HIF-overexpressing tumors: Deltex1 promotes p53-mediated apoptosis via down regulation of TYR-2/TRP2/DCT, 16/April/2015, 11.39 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Deltex1 increases the expression of p53