A recent study from the Department of Pathology, School of Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan shows that “Reduced FOXO1 expression accelerates skin wound healing and attenuates scarring.” This study was published in the 8 July 2014 issue of Am J Pathol by Prof Shimokawa, Mori R and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: MiRNA-based therapy for accelerated skin wound healing and for preventing pathological scarring: MiRNA-370 enhances wound healing and attenuates scarring via down regulation of its target gene
Significance:
This study suggests an MiRNA-based therapy for accelerated skin wound healing and for preventing pathological scarring: MiRNA-370 enhances wound healing and attenuates scarring via down regulation of its target gene healing therapy. MiRNA-370, by decreasing the expression of its target gene, it may: (1) increase keratinocyte migration; (2) decrease granulation tissue formation; and (3) attenuate inflammatory response. Thereby, it may (1) accelerate skin wound healing; and (2) prevent pathological scarring. Thus, pharmacological formulations encompassing “MiRNA-370 or its activators” may be used to (1) accelerate would healing; and (2) attenuate pathological scarring.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, MiRNA-based therapy for accelerated skin wound healing and for preventing pathological scarring: MiRNA-370 enhances wound healing and attenuates scarring via down regulation of its target gene, 20/April/2014, 11.20 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How MiRNA-370 accelerates wound healing and attenuates pathological scarring.
