A recent study from the Cardiovascular Division of the Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA; Massachusetts General Hospital Cardiovascular Division and Harvard Medical School, MA, USA shows that “miR-222 Is Necessary for Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling.” This study was published in the 7 April 2015 issue of Cell Metabolism (the number 1 journal in the field of Metabolism) by Prof Rosenzweig A, Xiaojun Liu and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Exercise Rescues the malfunctioning cardiomyocytes in myocardial patients: Exercise regenerates cardiomyocytes and improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10)
Significance:
Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; and were expected to be doubled by 2015; and (3) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars, there is an urgent need to find a safe treatment methodology to induce regeneration of cardiomyocytes that were lost in Myocardial patients.
This study suggests, for the first time, that Exercise, by increasing the expression of its target gene miRNA-222, it may increase the expression of PNUTS/PPP1R10. Thereby, it may: (1) inhibit DNA damage responses, (2) inhibit telomere shortening; and (3) promote cardimyocyte survival/regeneration. Further, it may increase cardiac repair and growth; and decrease remodeling after ischemic injury. Therefore, Exercise or Exercise-induced MiRNA-222, which mimics the function of exercise, may prevent ageing-associated decline in cardiac function. Together, pharmacological formulations encompassing “MiRNA-222 or its activators” may be used to improve cardiac function after myocardial infarction. Based on this finding, Physicians may consider recommending exercise therapy for cardiac patients.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Exercise Rescues the malfunctioning cardiomyocytes in myocardial patients: Exercise regenerates cardiomyocytes and improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 23/April/2014, 10.24 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Exercise increases the expression of PNUTS/PPP1R10
