A recent study from the Mammalian Genetics Laboratory, Cancer Research UK London Research Institute, Lincoln’s Inn Fields Laboratories, London, United Kingdom; and School of Medicine, King’s College London, London, United Kingdom shows that “Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, δ, and β Cells.“ This study was published in the August 7 2014 Cell Stem Cell (the number 1 journal in “Stem cell biology” with an impact factor of 23.563) by Prof Axel Behrens, Rocio Sancho, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Regenerating the lost pancreatic β cells in Diabetic patients: Icariin, a flavanoid and phosphodiestrase-5 inhibitor, promotes reprogramming of adult pancreatic ductal cells into α, δ, and β cells via up regulation of Ngn3. This study suggests that Icariin, by increasing the expression of Ngn3 in adult pancreatic ductal cells, it may reprogram adult pancreatic ductal cells into β cells. Thereby, it may induce the expression of Ngn3, increase insulin secretion and inhibit insulin resistance. Together, this study suggests that pharmacological formulations encompassing “Icariin or its analogues” may be used to regenerate β cells in T2D patients.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Regenerating the lost pancreatic β cells in Diabetic patients: Icariin, a flavanoid and phosphodiestrase-5 inhibitor, promotes reprogramming of adult pancreatic ductal cells into α, δ, and β cells via up regulation of Ngn3, 30/April/2015, 09.25 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Icariin increases the expression of Ngn3