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A recent study from the Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, USA; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA; The James Cancer Hospital, The Ohio State University, Columbus, OH, USA shows that Transcription factor foxo1 is a negative regulator of NK cell maturation and function. This study was published in the 10 March  2015 issue of Immunity (the number 1 journal in the field of Immunological research with an impact factor of  19.748) by Prof Yu J, Deng Y, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: MiRNA-based Immune augmentation therapy: MiRNA-96 promotes NK cell maturation and function via up regulation of its target gene.


This study suggests, for the first time, that MiRNA-96, by increasing the expression of its target gene, it may decrease the expression of FOXO1. Thereby, it may promote NK cell maturation and function. Thus, pharmacological formulations encompassing “MiRNA-96 activators” may be used to (1) increase NK cell function; and (2) eradicate large solid tumors. 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, MiRNA-based Immune augmentation therapy:  MiRNA-96 promotes NK cell maturation and function via up regulation of its target gene, 30/April/2014,  19.23,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Undisclosed information: How MiRNA-96 decreases Foxo1 expression and increases NK cell function.

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