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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, L., Natural product-based therapy for Metastatic tumors: Agaricus blazei Murill (AbM)a medicinal mushroom,  decreases the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 1/May/2015, 12.25 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: 

It has recently been shown that blocking PD-1 with antibodies one could make tumors shrink. This work, relating to Cancer immunotherapy, has been chosen as Science’s breakthrough of the year. 

The study presented here suggests that Agaricus blazei Murill (AbM)a medicinal mushroom,  by decreasing the expression of its target gene, it may suppress the expression of PD-1.  Thereby, it may activate the immune system and inhibit metastatic progression. Thus, pharmacological formulations encompassing Agaricus blazei Murill (AbM) or its analogues may be used to inhibit the progression of tumors.

Undisclosed information: How  Agaricus blazei Murill (AbM) suppresses the expression of PD-1

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