Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Significance: This study suggests a vitamin-based Anti-cancer stem cell/metastasis therapy. 1α, 25-dihydroxyvitamin D3 (Calcitriol), by increasing the expression of its target genes, it may decrease the expression of cancer stem-cell enriched and reprogramming protein Sox2. Thereby, it may inhibit migration and invasion of metastatic cancer cells. Thus, pharmacological formulations encompassing ” Calcitriol or its analogues” may be used to inhibit the progression of invasive tumors. Given that exposure to Sunlight increases the levels of 1,25-dihydroxyvitamin D, one may expose to the optimal level of sunlight to stall metastasis-associated cancer stem cell proliferation.
Undisclosed information: How Calcitriol decreases the expression of Sox2
Citation: Boominathan, L., Sunlight exposure stalls Cancer stem cell proliferation and metastatic cancer progression: Calcitriol (1α, 25-dihydroxyvitamin D3) decreases the expression of cancer stem-cell enriched reprogramming protein Sox2 and inhibits migration and invasion of metastatic cancer cells via down regulation of its target gene, 3/May/2015, 12.13 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Web: http://genomediscovery.org
Courtesy: When you cite drop us a line at info@genomediscovery.org