A recent study from the Department of Laboratory Medicine, University of California San Francisco, San Francisco, California 94143, USA; and Department of Haematology, University of Cambridge, Cambridge CB2 OAH, UK” shows that Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoid leukaemia. This study was published in the 10 March 2015 issue of the Online journal “Nature Communication” by Prof Müschen M, Buchner M and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product–based therapy for leukaemia: Cirsilol (3′,4′,5-trihydroxy-6,7-dimethoxyflavone), a flavone isolated from Achillea fragrantissima, suppresess B-cell lineage acute lymphoid leukaemia via up regulation of its target gene
Significance:
This study suggests a natural product-based therapy for human leukaemia: Cirsilol, by suppressing the expression of its target gene, it may inhibit the progression of B-cell lineage acute leukaemia. Thus, pharmacological formulations encompassing “Cirsilol or its analogues” may be used to inhibit B-cell lineage acute leukaemia.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Natural product-based therapy for leukaemia: Cirsilol (3′,4′,5-trihydroxy-6,7-dimethoxyflavone), a flavone isolated from Achillea fragrantissima, suppresess B-cell lineage acute lymphoid leukaemia via up regulation of its target gene, 12/June/2015, 11.13 pm,Genome-2-Bio-MedicineDiscoverycenter (GBMD), http://genomediscovery.org
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Undisclosed information: How Cirsilol inhibits the progression of B-cell lineage acute lymphoid leukaemia.