Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., A known drug of an unknown antiglycemic function: Sildenafil, a phosphodiesterase-5 inhibitor, increases B23/Nucleophosmin expression, β-cell replication and prevents diabetes development via up regulation of its target gene, 17/April/2014, 22.45, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: Sildenafil is used in the treatment of erectile dysfunction and pulmonary arterial hypertension. This study suggests, for the first time, that Sildenafil, by increasing the expression of its target gene, it may increase (1) the expression of B23/Nucleophosmin; and (2) β-cell replication Thereby, it may prevent the development and the progression of diabetes. Thus, pharmacological formulations encompassing “Sildenafil or its analogues“ may be used to treat diabetic patients.
Undisclosed information: How Sildenafil increases the expression of B23/Nucleophosmin