A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March 2013 issue of Nature by Prof Dimmler, Boon, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: A known drug of an unknown cardiomyocyte protective function: Sildenafil, a phosphodiesterase-5 inhibitor, improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10)
Significance:
Sildenafil is used in the treatment of erectile dysfunction and pulmonary arterial hypertension. This study suggests, for the first time, that Sildenafil, by increasing the expression of its target gene, it may increase the expression of PNUTS/PPP1R10. Thereby, it may: (1) inhibit DNA damage responses; (2) inhibit telomere shortening; and (3) promote cardimyocyte survival/regeneration. Thus, Sildenafil may (1) prevent ageing-associated decline in cardiac function; and (2) rescue the malfunctioning cardiomyocytes in myocardial patients. Together, pharmacological formulations encompassing “Sildenafil or its analogues” may be used to improve cardiac function after myocardial infarction.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, A known drug of an unknown cardiomyocyte protective function: Sildenafil, a phosphodiesterase-5 inhibitor, improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 22/April/2014, 23.27, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Sildenafil increases the expression of PNUTS/PPP1R10
