A known drug of an unknown function as an inhibitor of lipid accumulation and redistribution: Metformin, the widely used drug in the treatment of T2DM, inhibits lipid biosynthesis and lipid droplet formation via down regulation of its target gene, 1/May/2014, 11.27 am

A recent study from the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Pathology & Pathophysiology, School of Medicine, Zhejiang University, Zhejiang, China; and The Key Laboratory of Reproductive Genetics, Ministry of Education, Hangzhou, China shows that “FSH regulates lipid accumulation and redistribution in aging through the Gαi/Ca²⁺/CREB pathway.” This study was published in the 6 March  2015 issue of the journal “Aging cell” (the number 1 journal in “Aging” science) by Prof He-Feng Huang, Xin-Mei Liu, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: A known drug of an unknown function as an inhibitor of lipid accumulation and redistribution: Metformin, the widely used drug in the treatment of T2DM, inhibits lipid biosynthesis and lipid droplet formation via down regulation of its target gene

Significance: 

This study suggests, for the first time, an unknown function of a known drug Metformin. Metformin, by decreasing the expression of its target gene, it may: (1) inhibit lipid biosynthesis; and (2) lipid droplet formation.  Thus, pharmacological formulations encompassing “Metformin or its analogues” may be used to treat a number of lipid disorders. 

Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

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To cite: Boominathan, A known drug of an unknown function as an inhibitor of lipid accumulation and redistribution: Metformin, the widely used drug in the treatment of T2DM, inhibits lipid biosynthesis and lipid droplet formation via down regulation of its target gene, 1/May/2014, 11.27 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Undisclosed information: How Metformin inhibits (1) lipid biosynthesis; and (2) lipid droplet formation