Profs. Drs. R I Gregory, Camargo FD and their co-workers from Boston Children’s Hospital, MA, USA; Department of Biological Chemistry and Molecular Pharmacology and Department of Pediatrics, Harvard Medical School, Boston, MA, USA; and Harvard Stem Cell Institute, Boston, MA, USA had reported in the prestigious journal Cell (Feb 27, 2014) that “Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer”
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: A link between the regulation of Cell-density-dependent miRNA Biogenesis and tumor suppression: Fulvestrant/Faslodex, a selective estrogen receptor down-regulator, promotes widespread miRNA biogenesis via up regulation of its target gene. This data may suggest that Fulvestrant/Faslodex could function as a potent anti-cancer agent in metastatic breast cancers by activating the network of tumor suppressor miRNAs.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, A link between the regulation of Cell-density-dependent miRNA Biogenesis and tumor suppression: Fulvestrant/Faslodex, a selective estrogen receptor down-regulator, promotes widespread miRNA biogenesis via up regulation of its target gene, 24/April/2014, 13.53
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