A study from the Department of Orthopaedic Surgery, University of Michigan Medical School, USA; and Department of Molecular & Integrative Physiology, University of Michigan Medical School, USA shows that “Haploinsufficiency of myostatin protects against aging-related declines in muscle function and enhances the longevity of mice.” This study was published in the 15 March 2015 issue of the Journal “Aging cell” (the no.1 journal in aging) by Prof. Faulkner JA, Mendias CL, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Adding more years into your life with MicroRNAs: MiRNA-208 decreases aging-related decline in muscle function and enhances the longevity of mammals via down regulation Myostatin.
Significance: Myostatin is known to function as a key modulator of muscle mass and function. Prof. Faulkner JA and his team has shown recently that deficiency of myostatin protects against aging-related loss in muscle function and extends the maximum lifespan of mice.
I have published recently stating that miRNA-208 may extend the lifespan of mammals via down regulation of p70S6 Kinase (http://genomediscovery.org/mirna-based-life-span-extension-therapy-mirna-27a-inhibits-the-expression-of-ribosomal-protein-s6-kinase-1-p70s6-kinase-and-extends-mammalian-life-span-via-down-regulation-of-its-target-gene-7apr/.)
The present study suggests, for the first time, that MiRNA-208, by decreasing the expression of its target gene Myostatin, it may protect against aging-related loss of muscle function. And, thereby, extend the maximum lifespan of mice. Together, this study suggests that miRNA-208 may enhance longevity by suppressing both p70S6 Kinase and Myostatin. Thus, pharmacological formulations encompassing “miRNA-208 activators” may be used to enhance longevity.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Adding more years into your life with MicroRNAs: MiRNA-208 decreases aging-related decline in muscle function and enhances the longevity of mammals via down regulation myostatin, 10/April/2015, 23.27, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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