The 1989 Nobel prize winner in Physiology/Medicine, Prof. Bishop JM, Liu H and others from G.W. Hooper Foundation, University of California at San Francisco, San Francisco, California 94143, USA has published a research paper in the 13 May 2012 Nature Cell Biology (I.F: 20.058) stating that “MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits.” This study has published a paradoxical finding stating that c-Myc functions as a metastasis suppressor by turning off the expression of αv and β3 integrin subunits.
Based on this this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: Addressing Nobel laureate Bishop JM’s conundrum (c-MYC suppresses cancer metastasis): Does p53 function as a metastasis promoter in certain cellular contexts by increasing the expression of αv and β3 integrin subunits?. It is known for years that p53: (1) is an upstream regulator of c-myc expression; and (2) suppresses the expression of c-Myc via up regulation of its target gene. Considering Nobel laureate Bishop JM’s findings presented above, p53 may function as a metastasis promoter in certain cellular contexts by (1) suppressing the expression of c-Myc; and (2) increasing the expression of αv and β3 integrin subunits.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Web: http://genomediscovery.org
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
To cite: Boominathan, Addressing Nobel laureate Bishop JM’s conundrum (c-MYC suppresses cancer metastasis): Does p53 function as a metastasis promoter in certain cellular contexts by increasing the expression of αv and β3 integrin subunits?, 30/September/2014, 9.17 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Courtesy: When you cite drop us a line at info@genomediscovery.org
* Research cooperation