- A study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Cambridge, MA, USA has reported that “Mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts.”
- This study was published in the 09 May 2014 Circulation Research by Prof. Wang and others from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Cambridge, MA, USA.
- On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: AntagomiR-based Cardiac Regeneration therapy: MiRNA-490-3p inhibits myocardial proliferation in postnatal and adult hearts via down regulation of its target gene . This study suggests that MiRNA-490-3p, by suppressing the expression of its target gene, it could promote heart failure. Together, this study suggests that pharmacological formulations containing “AntagomiR-490-3p or MiRNA-490-3p inhibitors“ can be used to treat heart failure.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Web: http://genomediscovery.org
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To cite: Boominathan, L., AntagomiR-based Cardiac Regeneration therapy: MiRNA-490-3p inhibits myocardial proliferation in postnatal and adult hearts via down regulation of its target gene, 3/June/2014, 7.36 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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