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A recent study from Division of Pharmacology, Department Neuroscience, School of Medicine, Federico II University, Italy shows that “MicroRNA-103-1 Selectively Downregulates Brain NCX1 and Its Inhibition by Anti-miRNA Ameliorates Stroke Damage and Neurological Deficits.” This study was published in the July 22  2014 Molecular Therapy  by Prof  Pignataro Giuseppe, Antonio Vinciguerra, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: AntagomiR-based therapy for Stroke and Neurological deficits: Stress-induced gene product p53 exasperates stroke damage and neurological deficits via down regulation of brain Na+/Ca2+ exchanger  (NCX1)This study suggests that stress-induced p53, by decreasing the expression of NCX-1, it may aggravate brain damage and neurological deficits Together, this study suggests that pharmacological formulations encompassing“p53 suppressors” may be used to treat patients suffering from stroke and neurological deficits.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, L., AntagomiR-based therapy for Stroke and Neurological deficits: Stress-induced gene product p53 exasperates stroke damage and neurological deficits via down regulation of brain Na+/Ca2+ exchanger  (NCX1), 9/August/2014,  8.51 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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