Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., Anti-cancer stem cell therapy: AMP-Activated Protein Kinase α 2 (AMPKα2) suppresses the expression of stem cell proteins Oct-4 and Sox-2 and inhibits cancer stem proliferation via up regulation of its target gene, 27/March/2015, 12.05 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: The study presented here suggests that AMPKα2, by increasing the expression of its target genes, it may suppress the expression of stem cell/reprogramming proteins Oct-4 and Sox-2. Thereby, it may inhibit the proliferation of cancer stem cells. Thus, pharmacological formulations encompassing “AMPKα2 activators” may be used to inhibit the proliferation of cancer stem cells enriched in tumor tissues.
Undisclosed information: How AMPKα2 decreases the expression of Oct-4 and Sox-2
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