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A recent study shows that Twist1 induces endothelial differentiation of tumour cells through the Jagged1-KLF4 axis. This study was published in the August 22, 2014 issue of Nature communications by Prof. Wu KJ, Chen HF and others.

On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Anti-metastasis therapy: BMP2 (Bone Morphogenic protein-2) inhibits endothelial differentiation of tumor cells through down regulation of the Twist1-Jagged1-KLF4 axis.  This study suggests, for the first time, that BMP2, by up regulating its target genes, it may suppress the expression of Twist1, Jagged1 and KLF4. Thereby, it may inhibit endothelial differentiation of tumour cells. Together, this study suggests that pharmacological formulations encompassing “BMP2 or its activators may be used to treat metastatic tumors.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, L., Anti-metastasis therapy: BMP2 (Bone Morphogenic protein-2) inhibits endothelial differentiation of tumor cells through down regulation of the Twist1-Jagged1-KLF4 axis, Genome-2-Bio-Medicine Discovery center (GBMD), 25/08/2014, 7.51 am,  http://genomediscovery.org

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