Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Citation: Boominathan, L., Anti-metastasis therapy: GATA binding protein-6 inhibits invasive motility via down regulation of ICAT (Inhibitor of β-catenin and TCF), 22/October/2014, 20.09, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: This study suggests that GATA binding protein-6, by increasing the expression of its target gene, it may decrease the expression of EMT protein ICAT. Therefore, pharmacological formulations encompassing “GATA binding protein-6 activators“ may be used to treat metastatic cancers.
Undisclosed information: How GATA binding protein-6 decreases ICAT expression.
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