Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Citation: Boominathan, L., Anti-metastasis therapy: SMAD7 inhibits invasive motility via down regulation of ICAT (Inhibitor of β-catenin and TCF), 21/October/2014, 9.41 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: This study suggests that SMAD7, by increasing the expression of its target gene, it may decrease the expression of EMT protein ICAT. Therefore, pharmacological formulations encompassing “SMAD7 activators“ may be used to treat metastatic cancers.
Amount: $300
Undisclosed information: How SMAD7 decreases ICAT expression.
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