Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Citation: Boominathan, L., Anti-metastasis therapy: SMAD7 suppresses the expression of PD-1 , a suppressor of activation of T-cells, via down regulation of its target gene, 3/March/2015, 23.36, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance:
It has recently been shown that blocking PD-1 with antibodies one could make tumors shrink. This work, relating to Cancer immunotherapy, has been chosen as Science’s breakthrough of the year.
The study presented here suggests that SMAD7, by decreasing the expression of its target gene, it may suppress the expression of PD-1. Thereby, it may activate the immune system and inhibit metastatic progression. Thus, pharmacological formulations encompassing “SMAD7 activators“ may be used to inhibit the progression of tumors.
Amount: $ 500*
Undisclosed information: How SMAD7 decreases the expression of PD-1
Web: http://genomediscovery.org
Courtesy: When you cite drop us a line at info@genomediscovery.org