A study from Karolinska Institutet, Stockholm, Sweden shows that MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
This study was published in the April 10, 2014 Nature [I.F >35] by Prof. Thomas H, Dr Gad H and others from Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Anti-miRNA based cancer therapy: The reprogramming and stem cell protein Oct-4 promotes cancer development by increasing the expression of nucleotide sanitizing enzyme MTH1/NUDT1. This study may suggest that Oct-4, by down regulating its target gene, it may increase the expression of MTH1/NUDT1. Together, this study suggests that pharmacological formulations containing “small molecule inhibitors of Oct-4” may be used in the treatment of human cancers.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, L., Anti-miRNA based cancer therapy: The reprogramming and stem cell protein Oct-4 promotes cancer development by increasing the expression of nucleotide sanitizing enzyme MTH1/NUDT1, 3/July/2014, 6.55 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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