Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., Anti-MiRNA-based therapy for Dementias: Stress-induced miRNA-128 inhibits memory consolidation via down regulation of memory genes LIMK and CREB1, 14/October/2014, 6.39 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: This study has elucidated the mechanism by Stress-induced MiRNA-128 inhibits memory consolidation. MIRNA-128, by suppressing the expression of its target gene, it could decrease the expression of memory genes such as LIMK and CREB1. This result suggests that, by suppressing the expression of miR-128, one could increase the expression of memory consolidation genes. Thus, pharmacological formulations encompassing “MIRNA-128 inhibitors” can be used to treat patients suffering from dementias.
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