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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, L., Anti-MiRNA-based therapy for Dementias: Stress-induced miRNA-29 inhibits memory consolidation via down regulation of memory genes LIMK and CREB1, 13/October/2014, 8.01 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: This study has elucidated the mechanism by Stress-induced MiRNA-29 inhibits memory consolidation. MIRNA-29, by suppressing the expression of its target gene, it could decrease the expression of memory genes such as LIMK and CREB1. This result suggests that, by suppressing the expression of miR-29, one could increase the expression of memory consolidation genes. Thus, pharmacological formulations encompassing “MIRNA-29 inhibitors can be used to treat patients suffering from dementias.

Web: http://genomediscovery.org

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