Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., Antimetastasis therapy: Metformin, the widley used drug in the treatment of T2M, suppresses the expression of actin-regulatory proteins FHOD1 and PPM1F and inhibits migration and invasion of metastatic cancer cells via up regulation of its target gene, 25/March/2015, 21.55, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: The study presented here suggests that Metformin, by increasing the expression of its target genes, it may suppress the expression of actin-regulatory proteins FHOD1 and PPM1F. Thereby, it may inhibit migration and invasion of metastatic cancer cells. Thus, pharmacological formulations encompassing “Metformin or its analogues” may be used to inhibit the progression of invasive tumors.
Undisclosed information: How Metformin decreases the expression of FHOD1 and PPM1F
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