A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the March 7 2013 issue of Nature by Prof Dimmler, Boon, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: AntiMiRNA-based therapy for Myocardial Infarction: Stress-induced protein Sirtuin-6 inhibits myocardial function after myocardial infarction via down regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10. By increasing the expression of Sirtuin-6 in cardiomyocytes, one may prevent ageing-associated decline in cardiac function. Together, this study suggests that pharmacological formulations encompassing “Sirtuin-6 or its activators” may be used to improve cardiac function after myocardial infarction.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, L., AntiMiRNA-based therapy for Myocardial Infarction: Stress-induced protein Sirtuin-6 inhibits myocardial function after myocardial infarction via down regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10, 09/September/2014, 06.04 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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