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May 2, 2015
Published by admin_auro at May 2, 2015
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Small molecule-based Lifespan extension therapy: PDGF-B inhibits senescence and extends life span by down regulating the expression of adenylate cyclase 5 (ADCY5), 2/May/2015, 07.08 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Small molecule-based Lifespan extension therapy: PDGF-B inhibits senescence and  extends life span by down regulating the […]
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May 2, 2015
Published by admin_auro at May 2, 2015
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Molecular therapy for Metastatic human tumors: Ndfip1 inhibits cellular proliferation, invasion and metastasis by increasing the expression of metastasis suppressor BTG2 via down regulation of its target gene, 2/May/2015, 6.45 am

A study from the Cell Pathology Division, The Children’s Hospital of Philadelphia, Philadelphia, USA shows that “TGF-β induces the expression of the adaptor Ndfip1 to silence IL-4 production […]
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May 2, 2015
Published by admin_auro at May 2, 2015
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MiRNA-based Exercise-Mimicking pills may inhibit Insulin resistance and decrease adiposity: MiRNA-1269 decreases gluconeogenesis genes, such as PEPCK and G6Pase, reduces hepatic glucose production, improves muscle insulin sensivitity and decreases adiposity via up regulation of its target gene, 2/May/2015, 6.36 am

Significance: This study suggests, for the first time, that MiRNA-1269, by decreasing the expression of its target gene, may: (1) decrease the expression of gluconeogenesis genes, such as […]
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May 1, 2015
Published by admin_auro at May 1, 2015
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Natural product-based therapy for pulmonary diabetic cardiomyopathy: Succinate, one of the component of TCA cycle, inhibits the development of diabetic cardiomyopathy via down regulation of its target gene Foxo1, 1/May/2015, 23.08

A study from the Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, Texas 75390-8573, USA shows that “Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice.” This […]
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