Insights into the treatment of Th2-mediated inflammation and allergic diseases: Neurotensin alleviates Th2-medited inflammation and Allergy via up regulation of its target gene, 18/July/2014, 6.59 am

A study from the University of California, Los Angeles; California Institute of Technology, Pasadena; Medical Research Council, National Institute for Medical Research, London has reported that “Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminthimmunity.” This study was published in the July 14, 2014 Proc Natl Acad Sci U S A [I.F >10] by Prof. Wilson, The 1975 Nobel […]

Molecular therapy for Human Cancer: Busulfan (1,4-butanediol dimethanesulfonate)/Myleran/Busulfex IV suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) via up regulation of its target gene, 18/July/2014, 6.17 am

The 1989 Noble prize winner in Chemistry, Prof. Thomas R. Cech from the University of Colorado BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; I.F: >35) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function. In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: Molecular therapy for Human Cancer: Busulfan(1,4-butanediol dimethanesulfonate)/Myleran/Busulfex […]

Therapeutic insights into the regulation of brown/white adipocyte determination: MiRNA-103 promotes lipodystrophy via down regulation of its target gene, 18/July/2014, 5,33 am

A study from the Section on Integrative Physiology-Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.  has reported that “Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy.” This study was published in the June 1, 2014 Journal of Clinical Investigation (JCI) [I.F >15] by Prof. C. Ronald Kahn, Mori AM and others from the Integrative Physiology-Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA “ On the foundation […]

Myeloid differentiation: The reprogramming and stem cell protein Oct4 inhibits the expression of CBFB via up regulation of its target gene, 18/July/2014, 5.21 am

Idea Proposed/Formulated by: Dr L Boominathan PhD Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Myeloid differentiation: The reprogramming and stem cell protein Oct4 inhibits the expression of  CBFB via up regulation of its target gene, 18/July/2014, 5.21 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org * Research cooperation

Insight into the treatment of Metastatic Pancreatic/intestine/ovarian Cancer: Tumor suppressor p33(ING1b) suppresses the expression of PDGF Receptor β (PDGFRβ) via up regulation of its target gene, 18/July/2014, 5.14 am

A study from Watson School of Biological Sciences shows that Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling. This study was published in the April 10, 2014 Cell by Prof. Dr Scott Lowe, Watson School of Biological Sciences, CSHL, New York; Prof. Dr Carol Prives, Department of Biological Sciences, Columbia University, New York; and others. On the foundation of this interesting finding, Dr […]

Natural agents that enhance Cellular Reprogramming: Garlic enhances the generation of induced pluripotent stem cells via up regulation of NRF2, 18/July/2014, 4.48 am

Idea Proposed/Formulated by: Dr L Boominathan PhD Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Natural agents that enhance Cellular Reprogramming: Garlic enhances the generation of induced pluripotent stem cells via up regulation of NRF2, 18/July/2014, 4.48 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org * Research cooperation