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January 16, 2019

The erectile dysfunction drug sildenafil may protect against Myocardial Infarction: Sildenafil (brand name: viagra), a PDE5 inhibitor used in the treatment of erectile dysfunction and pulmonary hypertension, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 16/January/2019, 11.55 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of of […]
January 16, 2019

RNA-based therapy for aging-associated diseases and Lifespan extension: LncRNA HULC  inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging, via down-regulation of its target gene, 16/January/2019, 11.33 pm

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
January 16, 2019

Molecular therapy for glaucoma: Trimetazidine (TMZ), the drug used in the treatment of angina pectoris,  increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against glaucoma,  via down regulation of its target gene, 16/January/2018, 11.27 pm

Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, […]
January 16, 2019

Mechanistic insights into how Fasudil functions as a learning/memory/cognitive-enhancer:  Fasudil (brand name: hydroxyfasudil), a vasodilator used in the treatment of pulmonary hypertension, stroke and others, increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 16/January/2019, 11.18 pm

Introduction: What they say: A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center […]
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