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April 2, 2015

Small molecule-based Life-span extension therapy: Sox2 inhibits senescence and extends life span by down regulating the expression of adenylate cyclase 5 (ADCY5), 2/April/2015, 11.26 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Small molecule-based Life-span extension therapy: Sox2 inhibits senescence and  extends life span by down regulating the […]
April 2, 2015

Molecular therapy for pulmonary arterial hypertension: Succinate, an intermediate in the TCA cycle, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene, 2/April/2015, 10.57 am

A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in […]
April 2, 2015

Natural product-based therapy for hypertensive cardiovascular diseases: EF24 (curcumin analog) suppresses Ang II-induced hypertensive cardiac remodelling via down regulation of its target gene, 2/April/2015, 07.04 am

A recent study from the Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, China shows that “Smad7 inhibits angiotensin II-induced hypertensive […]
April 2, 2015

Natural product-based therapy for regional enteritis disease: 17β-E2 (An Estrogen derivative) increases the expression of immunosuppressive cytokine TGF-β1 and inhibits the progression of regional enteritis disease via up regulation of its target gene, 2/April/2015, 6.53 am

A recent study from the Department of Systems Medicine, University of Tor Vergata, Italy shows that Mongersen, an oral SMAD7 antisense oligonucleotide, inhibits regional enteritis disease. This study was published in […]
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