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August 24, 2018
Published by admin_auro at August 24, 2018
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Combinatorial therapy for Deafness: A therapeutic mix encompassing Exemestane, Cholecalciferol, Ajoene and DIM (ECAD)  increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via upregulation of its target genes, 24/August/2018, 10.45 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Combinatorial therapy for Deafness: A therapeutic mix encompassing Exemestane, Cholecalciferol, Ajoene and DIM (ECAD)  increases the expression […]
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August 24, 2018
Published by admin_auro at August 24, 2018
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Serelaxin (SLX)-based therapy for cardiac hypertrophy and fibrosis: Serelaxin (SLX), a recombinant relaxin-2, decreases MiR-29 expression, activates Wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1 and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via upregulation of its target gene, 24/August/2018, 2.52 pm

Introduction: What they say: A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]
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August 23, 2018
Published by admin_auro at August 23, 2018
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Thyroid hormones come to the rescue of blood sugar disease: Levothyroxine (T4) and Liothyronine(T3)-based therapy for autoimmune diabetes (TIDM): Thyroxine/Levothyroxine (T4) and Liothyronine/Triiodothyronine (T3) increase PD-L1 expression, increases Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up-regulation of its target gene, 23/August/2018, 11.35 pm

Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and Clinical […]
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August 23, 2018
Published by admin_auro at August 23, 2018
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Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  IGFBP3, PIAS3, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 23/August/2018, 2.58 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
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