Molecular therapy for glaucoma: Valproic acid (brand name: Convulex and others), used in the treatment of epilepsy, bipolar disorder, migraine headaches and others, increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against glaucoma, via down regulation of its target gene, 20/April/2018, 12.21 pm
Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, USA; The Howard Hughes Medical Institute, Bar Harbor, ME 04609, USA shows that “Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice.” This research paper was published, […]
A sweetest way to say no to blood sugar disease: Natural sweetener-based therapy for TIIDM: Phyllodulcin, a natural sweetener 400-800 times sweeter than sugar, increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of its target gene Lin28, 20/April/2018, 11.11 am
Introduction: What they say: A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published, in the 30 September 2011 issue of the Journal “Cell” [One of the best journals in Biological sciences with an I.F of 28.71], by Prof George Q, the present Dean […]
Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Amitriptyline (trade name: Elavil), a medication used to treat major depressive disorder, anxiety disorder, and bipolar disorder, increases the expression of tumor suppressors genes, such as TA-p73/p63, TPM1, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 18/April/2017, 11.41 pm
From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53 pathway is altered in about 80% of tumors.; (3) our understanding is incomplete in terms of molecular targets and the oncogenic/malignant pathways involved in mutant […]
An essential oil-based therapy for Deafness: A therapeutic mix encompassing Rosa mosqueta oil, Cholecalciferol, Ajoene and DIM (RMCAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration, improves hearing loss via up regulation of its target genes, 18/April/2018, 11.25 pm
What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: An essential oil-based therapy for Deafness: A therapeutic mix encompassing Rosa mosqueta oil, Cholecalciferol, Ajoene and DIM (RMCAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration, improves hearing loss via up regulation of its target genes […]
Androsterone-based therapy for blood sugar disease (autoimmune diabetes (TIDM)): Dehydroepiandrosterone (DHEA) and its metabolite HE3286 (17α-ethynyl-5-androstene-3β,7β,17β-triol) increase PD-L1 expression, augment Tregs function, promote immune tolerance, increase pancreatic β-cell proliferation and regeneration, increase insulin secretion, improve insulin sensitivity, increase energy utilization, and reverse TIDM, via up regulation of its target gene, 18/April/2018, 10.40 pm
Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and Clinical Sciences, University of Milan, Milan 20157, Italy; and Nephrology Division, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA shows that “PD-L1 genetic overexpression or pharmacological restoration in […]
Bonding your way to keep cardiac diseases at bay: Oxytocin-based intranasal inhalation therapy for cardiac rejuvenation: Oxytocin, a peptide hormone and neuropeptide known to play a role in empathy, generosity, child birth and so on, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy via up regulation of its target gene, 18/April/2018, 10.17 pm
What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: A noble way to keep cardiac diseases at bay: Noble gas xenon-based cardiac rejuvenation therapy: Inhalation of Xenon gas suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy via up regulation of its target gene From the Significance of the study to Public […]