Antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Suramin (trade name: Moranyl, Naganin, Naganine and others), a drug used in the treatment of sleeping sickness and others, increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 10/April/2018, 7.17 pm
Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France shows that “Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses.” This research paper was published, in the 10 August 2016 issue of the journal […]
Natural product-derived therapy for Metastatic human tumors: Solasodine, isolated from solanum melongena, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 10/April/2018, 7.04 pm
Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China shows that “c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.” This study was published, in the 5 January 2017 issue of the […]
Natural product-based therapy for CyclinD3-CDK6 overexpressing cancers: Nimbolide, isolated from Azadirachta indica, inhibits the activity of glycolytic enzymes 6-phosphofructokinase and pyruvate kinase M2, decreases antioxidants NADPH and glutathione levels, increases reactive oxygen species levels, promotes apoptosis, and inhibits the progression of CyclinD3-CDK6 overexpressing cancers via down regulation of its target gene, 10/April/2018, 6.41 pm
Introduction: What they say A study from Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; and Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA shows that “The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival.” This research paper was published, in the 15 June 2017 issue of the journal “Nature” […]
Natural product-based therapy for blood-stage Plasmodium infection: Moringin, isolated from moringa olifera, decreases the expression of CTLA-4, PD-L1 and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clear blood-stage malaria via up regulation of its target gene, 10/April/2018, 6.29 pm
Introduction: What they say A study from the Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA shows that “Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4.” This research paper was published, in September 2017 issue of the journal “Nature Medicine” [One of […]
Combinatorial therapy for gynecologic cancers: A therapeutic mix encompassing Calcitriol, Mitoxantrone, Despiramine, 17DMAG, Salinomycin, Lovastatin, and Jasmonate inhibits the expression of HDAC6, acetylates tumor suppressor proteins, activates tumor suppressor function, and stifles the progression of ARID1A-mutated ovarian cancers via up-regulation of its target gene, 10/April/2018, 6.05 pm
Introduction: What they say: A study from Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA shows that “ARID1A-mutated ovarian cancers depend on HDAC6 activity” This study was published, in the 24 July 2017 issue of the journal “Nature Cell biology” [One of the best journals in Cell Biology with an I.F […]
An omega-3 way to treat pain: PUFA-based activation of the PD-1 pathway for Pain therapy: ω-PUFAs (Docosahexaenoic acid (DHA) + Eicosapentaenoic acid (EPA) increase the expression of PD-L1, attenuate acutes and chronic pain, suppress mechanical and thermal hypersensitivity and inhibit nociceptive neuron excitability, via up-regulation of its target gene, 9/April/2018, 6.31 am
Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China; and Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, US, shows that “PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron […]