admin_auro

August 27, 2018

Published by admin_auro at August 27, 2018

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Cancer
Ideas

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as FBOX11, Sprouty1/2, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 28/August/2018, 12.17 am

From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]

August 27, 2018

Published by admin_auro at August 27, 2018

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Repurposing an anti-diabetic drug into an anti-cancer drug: Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Pioglitazone (trade name: Actos), an anti-diabetic drug, increases the expression of tumor suppressors genes, such as TIMP3, CCM3/KRIT1, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 28/August/2018, 12.09 am

From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]

August 27, 2018

Published by admin_auro at August 27, 2018

Categories

A sere(ne)laxin-way to stay free of cardiac diseases: Serelaxin-based therapy for attenuating pathogenesis-associated with Myocardial infarction: Serelaxin, a recombinant Relaxin-2, decreases IRF3 (Interferon regulatory transcription factor-3), GM-CSF (Granulocyte-macrophage colony-stimulating factor) and GRK2(G protein-coupled receptor kinase) expression, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits ventricular dilation, and promotes heart repair and survival, via up-regulation of its target gene, 27/August/2018, 11.25 pm

Introduction: What they say: A recent study from Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA; and Cardiovascular Research Center, Massachusetts General Hospital and […]

August 26, 2018

Published by admin_auro at August 26, 2018

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Repurposing the reproductive hormone relaxin into a cardioprotective drug : Cardiac rejuvenation therapy: Relaxin, a protein hormone that facilitates labor and relaxes the uterine musculature, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy via upregulation of its target gene, 26/August/2018, 11.30 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Repurposing the reproductive hormone relaxin into a cardioprotective drug : Cardiac rejuvenation therapy: Relaxin, a […]