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January 12, 2019
Published by admin_auro at January 12, 2019
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Ribonucleic acid-based therapy for cardiomyocyte proliferation and heart regeneration: LncRNA XIST decreases tumor suppressor MiR-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up regulation of its target gene, 12/January/2018, 8.11 am

Introduction: What they say: A recent study from Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA; Key Laboratory […]
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January 12, 2019
Published by admin_auro at January 12, 2019
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Ribonucleic acid-based therapy for Myocardial Infarction: LncRNA ADAM12 inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 12/January/2019, 7.40 am

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of of […]
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January 12, 2019
Published by admin_auro at January 12, 2019
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Repurposing the anti-hypertensive agent Manidipine into an anti-diabetic agent: Manidipine (Trade name: Manyper), an antihypertensive agent, increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28, 12/January/2019, 7.14 am

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis […]
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January 12, 2019
Published by admin_auro at January 12, 2019
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Ribonucleic acid-based therapy for aging-associated diseases and Lifespan extension: LncRNA Zeb2-AS1 increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging via down-regulation of its target gene, 12/January/2019, 6.39 am

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
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