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Dr.Boomi

Natural product-therapy for Deafness: A therapeutic mix encompassing Tadalafil, Cholecalciferol, Ajoene and DIM (TCAD)  increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via up regulation of its target genes, 20/January/2018, 10.57 am
Natural product-therapy for Deafness: A therapeutic mix encompassing Tadalafil, Cholecalciferol, Ajoene and DIM (TCAD)  increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via up regulation of its target genes, 20/January/2018, 10.57 am 960 720 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Natural product-therapy for Deafness: A therapeutic mix encompassing Tadalafil, Cholecalciferol, Ajoene and DIM (TCAD)  increases the expression of ATG5 (Autophagy-related 5),…

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Molecular therapy for Metastatic cancers: Metformin, an anti-hyperglycemic drug, increases the expression of tumor/metastatic suppressors TPM1 and TAp63, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 20/January/2018, 10.47 pm
Molecular therapy for Metastatic cancers: Metformin, an anti-hyperglycemic drug, increases the expression of tumor/metastatic suppressors TPM1 and TAp63, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 20/January/2018, 10.47 pm 960 720 Dr Boomi's Genom-2-Discovery Center

From significance of the study to Public health relevance:  Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them…

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 Antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Xanthohumol, isolated from Hops, increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 20/January/2018, 10.37 pm
 Antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Xanthohumol, isolated from Hops, increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 20/January/2018, 10.37 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France shows that…

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Natural product-derived therapy for attenuating pathogenesis-associated with Myocardial infarction: A pharmaceutical mixture encompassing β-Cryptoxanthin, Mangiferin and Glycyrrhetinic acid(CMG)decreases IRF3, GM-CSF (Granulocyte-macrophage colony-stimulating factor) and GRK2(G protein-coupled receptor kinase) expression, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits ventricular dilation, and promotes heart repair and survival via up regulation of its target gene, 19/January/2018, 11.58 pm
Natural product-derived therapy for attenuating pathogenesis-associated with Myocardial infarction: A pharmaceutical mixture encompassing β-Cryptoxanthin, Mangiferin and Glycyrrhetinic acid(CMG)decreases IRF3, GM-CSF (Granulocyte-macrophage colony-stimulating factor) and GRK2(G protein-coupled receptor kinase) expression, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits ventricular dilation, and promotes heart repair and survival via up regulation of its target gene, 19/January/2018, 11.58 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A recent study from Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA; and Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston,…

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Natural product-based exercise mementics therapy for Metabolic disease:Fisetin, isolated from A. Greggi, A. Berlanderi, Strawberry among others, increases PPARδ  and Foxo1 levels, inhibits glucose catabolism, preserves glucose levels, stimulates FA catabolism, delays the onset of hypoglycemia and boosts endurance exercise via down regulation of its target gene, 19/January/2018, 11.20 pm
Natural product-based exercise mementics therapy for Metabolic disease:Fisetin, isolated from A. Greggi, A. Berlanderi, Strawberry among others, increases PPARδ  and Foxo1 levels, inhibits glucose catabolism, preserves glucose levels, stimulates FA catabolism, delays the onset of hypoglycemia and boosts endurance exercise via down regulation of its target gene, 19/January/2018, 11.20 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say  A study from Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA shows that “CRY1/2 Selectively Repress…

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Natural product-based therapy for Diabetic retinopathy: A pharmaceutical mixture encompassing Melatonin, Epicatechin and Matrine (MNEM) inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down regulation of its target gene, 19/January/2018, 10.59 pm
Natural product-based therapy for Diabetic retinopathy: A pharmaceutical mixture encompassing Melatonin, Epicatechin and Matrine (MNEM) inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down regulation of its target gene, 19/January/2018, 10.59 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany; and German Centre for Cardiovascular Research (DZHK) partner…

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