Lifespan extension therapy: Glimpride, an anti- hyperglycemic medication, increases life span via up-regulation of its target gene BubR1, 8/October/2016, 11.59 pm

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July  2014 issue of the […]

Natural product-derived combination therapy for blood-stage Plasmodium infection: A therapeutic mix encompassing Clindamycin, Artemisinin, Doxycyclin, and Quinidine [CADQ]  decreases the expression of CTLA-4, PD-L1 and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clear blood-stage malaria via up regulation of its target gene, 8/October/2017, 11.55 pm

Introduction: What they say A study from the Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA shows that “Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4.” This research paper was published, in September 2017 issue of the journal “Nature Medicine” [One of […]

Natural product-based exercise mementics therapy for Metabolic disease: A therapeutic mix encompassing Lutein, Lycopene and Gastrodin (LLG) increases PPARδ  and Foxo1 levels, inhibits glucose catabolism, preserves glucose levels, stimulates FA catabolism, delays the onset of hypoglycemia and boosts endurance exercise via down regulation of its target gene, 8/October/2017, 1.06 am

Introduction: What they say  A study from Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA shows that “CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity.” This research paper was published, in the 2 May 2017 issue of the journal “Cell Metabolism” [One of the best […]

Natural product-based therapy for ageing-associated diseases: A therapeutic mix encompassing Fucoxanthin, Ursolic acid and Naringenin (FUN), isolated from Brown algae, Olive oil, Miralis Jalba, and Grape fruits, respectively, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging via down regulation of its target gene, 8/October/2017, 12.57 pm

  Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, New South Wales 2052, Australia shows that “A conserved NAD+ binding pocket that regulates […]

Natural product-based Anti-ageing and Life extension therapy:  A pharmaceutical mixture encompassing Cepharanthine, Edaravone, Eugenol (bis), Isoliquiritigenin, Taxifolin (CEEIT) increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels and enhances lifespan via down regulation of its target gene, 08/October/2017, 7.17 am

Introduction: What they say A study from Institute for Cell Biology, University of Bonn, Ulrich-Haberland Str.  Bonn, Germany; and Institute for Genetics and CECAD Research Center, University of Cologne, Joseph-Stelzmann Str. Cologne, Germany shows that “The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover.” This research paper was published, in […]

Lifespan extension therapy: Nateglinide, an anti- hyperglycemic medication,   increases life span via up-regulation of its target gene BubR1, 8/October/2016, 7.01 am

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July  2014 issue of the […]